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MASTERKEY-265: A phase III, randomized, placebo (Pbo)-controlled study of talimogene laherparepvec (T) plus pembrolizumab (P) for unresectable stage IIIB–IVM1c melanoma (MEL)

Background In the phase Ib part of MASTERKEY-265, T + P showed promising complete response rate (CRR) of 33% in 21 patients (pts) with advanced MEL. Here we report efficacy and safety from the phase III, randomized, double-blind MASTERKEY-265/KEYNOTE-034 study of T + P vs Pbo + P in pts with stage IIIB–IVM1c MEL (NCT02263508)....

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The effect of COVID-19 emergency in the management of melanoma in Italy

Abstract The COVID-19 pandemic has severely hampered the functioning of any health system, absorbing a considerable amount of resources and with the threat of widespread infection in the health services. The present survey has been carried out in Italy to evaluate if and how COVID-19 also affected skin melanoma management. We enrolled 13 Italian centres...

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Consensus Guidelines for the Management of Melanoma during the COVID-19 Pandemic: Surgery, Systemic Anti-cancer Therapy, Radiotherapy and Follow-up

Consensus Guidelines for the Management of Melanoma during the COVID-19 Pandemic: Surgery, Systemic Anti-cancer Therapy, Radiotherapy and Follow-up The current COVID-19 pandemic has major implications for the ability to deliver normal care for patients. Although Sir Simon Stevens, Chief Executive of NHS England, recommends ‘referrals, diagnostics and treatment to be brought back to pre-pandemic levels...

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The magnitude of COVID-19’s effect on the timely management of melanoma and nonmelanoma skin cancers

The magnitude of COVID-19’s effect on the timely management of melanoma and nonmelanoma skin cancers. To the Editor: The coronavirus disease 2019 (COVID-19) pandemic substantially reduced patient volumes or caused full closings of many US dermatology practices.1 , 2 Given reduced access to care and National Comprehensive Cancer Network guidelines to defer surgical management,3 concerns...

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Estimated impact of the COVID-19 pandemic on cancer services and excess 1-year mortality in people with cancer and multimorbidity: near real-time data on cancer care, cancer deaths and a population-based cohort study

Estimated impact of the COVID-19 pandemic on cancer services and excess 1-year mortality in people with cancer and multimorbidity: near real-time data on cancer care, cancer deaths and a population-based cohort study   Objectives To estimate the impact of the COVID-19 pandemic on cancer care services and overall (direct and indirect) excess deaths in people...

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Clinical impact of COVID-19 on patients with cancer (CCC19): a cohort study

Clinical impact of COVID-19 on patients with cancer (CCC19): a cohort study   Background Data on patients with COVID-19 who have cancer are lacking. Here we characterise the outcomes of a cohort of patients with cancer and COVID-19 and identify potential prognostic factors for mortality and severe illness. Methods In this cohort study, we collected...

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Mortality due to cancer treatment delay: systematic review and meta-analysis

Mortality due to cancer treatment delay: systematic review and meta-analysis. Abstract Objective To quantify the association of cancer treatment delay and mortality for each four week increase in delay to inform cancer treatment pathways. Design Systematic review and meta-analysis. Data sources Published studies in Medline from 1 January 2000 to 10 April 2020. Eligibility criteria...

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Melanoma and COVID-19: A narrative review focused on treatment

Melanoma and COVID-19: A narrative review focused on treatment Abstract Melanoma is the most severe form of skin cancer and its incidence has increased over the past few decades. COVID-19 pandemic affected the diagnosis and management of many diseases including melanoma. In this study, we aimed to provide a review focused on the diagnosis and...

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The danger of neglecting melanoma during the COVID-19 pandemic

The danger of neglecting melanoma during the COVID-19 pandemic Abstract Due to the COVID-19 pandemic, planned medical and surgical activities are being postponed. For the dermatology community, this interruption to the healthcare system can lead to delays in the diagnosis and treatment of melanoma. Neglecting melanoma during this crisis can result in increased mortality, morbidity...

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Crossover and rechallenge with pembrolizumab in recurrent patients from the EORTC 1325-MG/Keynote-054 phase 3 trial, pembrolizumab versus placebo after complete resection of high-risk stage III melanoma.

Crossover and rechallenge with pembrolizumab in recurrent patients from the EORTC 1325-MG/Keynote-054 phase 3 trial, pembrolizumab versus placebo after complete resection of high-risk stage III melanoma. Authors: Alexander M. Eggermont, Andrey Meshcheryakov, Victoria Atkinson, Christian U. Blank, Mario Mandalà, Georgina V. Long, Catherine Barrow, Anna Maria Di Giacomo, Rosalie Stephens, Shahneen Kaur Sandhu, Ragini Reiney...